Do antidepressants work?

Resultado de imagem para Do antidepressants work? Photo by Robert Brook/Science Photo Library

Photo by Robert Brook/Science Photo Library

Depression is a very complex disorder and we simply have no good evidence that antidepressants help sufferers to improve

by Jacob Stegenga is a lecturer in philosophy of science at the University of Cambridge. He is the author of Medical Nihilism (2018). He lives in Cambridge.
Edited by Sam Haselby

Your grief and guilt overwhelm you. You are so tired you cannot think straight. Your simple joys are lost in an invisible agony. You have pain in your head and back and stomach, real pain. The swamp of your soul suffocates you with despair. All this is your fault, you are worthless, and you might as well die. This is how depression can feel, though people’s experiences of it, including the severity of symptoms, can vary widely. This terrible disease affects about one person in 10 at some point in life and, to treat it, many millions of people have taken antidepressants. Unfortunately, we now have good reasons to think that antidepressants are not effective.

To know if antidepressants work we must, of course, pay close attention to the best evidence about these drugs. There have been many empirical trials of antidepressants, and in the past 10 years or so there have been some good meta-analyses of these trials (a meta-analysis pools data from multiple trials into a single analysis). However, there is a problem: experts disagree about the merits and problems of these empirical studies, and about what we should conclude based on them. Philosophy can help. Philosophy of science is the discipline that studies the concepts and methods of science, and offers a lens through which we can understand what scientific evidence shows us about the world. After witnessing the darkness of depression and the struggle by some of my dearest friends and family to treat this disease with drugs, I began to use my training as a philosopher to understand the evidence about antidepressants. Diving into the details of how antidepressant data are generated, analysed and reported tells us that these drugs are barely effective, if at all.

Depression affects many of us. To the extent that you find the arguments in this essay convincing, the message here could be disappointing. If you are already taking antidepressants, you might decide to stop, but I urge caution. We have little reliable evidence about coming off antidepressants, though there is evidence that people can suffer from withdrawal. Moreover, we have little reliable evidence about alternative modes of intervention, such as talk therapy or lifestyle changes. So, patients should be extra cautious when considering changes to their medications, or foregoing them for other kinds of treatments. A quick essay on a difficult subject must sacrifice depth; for a fuller presentation of the arguments that follow, please see my book Medical Nihilism (2018). If you are depressed, your physician or psychiatrist has clinical experience and insight into your condition – despite the fact that most physicians overestimate the benefits and underestimate the harms of antidepressants, you should continue to consult with them, perhaps with this essay in hand.

The best evidence about the effectiveness of antidepressants comes from randomised trials and meta-analyses of these trials. The vast majority of these studies are funded and controlled by the manufacturers of antidepressants, which is an obvious conflict of interest. These trials often last only weeks – far less than the duration that most people are on antidepressants. The subjects in these trials are selected carefully, typically excluding patients who are elderly, who have other diseases, or who are on several other drugs – in other words, the very kinds of people who are often prescribed antidepressants – which means that extrapolating the evidence from these trials to real patients is unreliable. The trials that generate evidence seeming to support antidepressants get published, while trials that generate evidence suggesting that antidepressants are ineffective often remain unpublished (this widespread phenomenon is called ‘publication bias’). To give one prominent example, in 2012 the UK pharmaceutical company GlaxoSmithKline pleaded guilty to criminal charges for promoting the use of its antidepressant Paxil in children (there was no evidence that it was effective in children), and for misreporting trial data…

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